Geneza życia według Christiana de Duve

Abstract

Christian de Duve is a laureate in Nobel Prize in Physiology or Medicine, in 1974 with Albert Claude and George E. Palade for describing the structure and functioning of cellular organelles such as lysosomes and peroxisomes. It also deals with the issue of the origins of life, developing theories of its origin on the basis of the hypothesis of the so-called, “The original broth”, the creation of life in the ocean of the original amino acid, in which chemical reactions are catalyzed by ultraviolet light.This article attempts to show the essential aspects of forming the core of his hypothesis on the origin of life on original Earth. Christian de Duve focuses the attention at the determinants of the historical development of the first animated system in which, with available before 3.5 billion years of simple chemical compounds, has been to create a primitive molecule RNA (ribonucleic acid). This process started so there: “RNA” world. “RNA” world which is the result of a particular order, of successive chemical reactions, as determined Nobel Prize winner, protometabolism. Protometabolism includes reactions that generated the ‘RNA world’ and maintain it all the time in existence. Protometabolism is the foundation for further process, which resulted in the emergence of the contemporary metabolism, protein-based enzymes... Mention the transition from simple molecules to create protometabolism autocatalist cycles, to take place, according to C. de Duve, through the use catalytic capabilities of molecules, such as trioesters - organic compounds, the sulfur analogues of esters. In the described hypothesis, the first in the history of metabolic reactions derive energy from breaking trioesters bonds. Exchange the metabolism into protometabolism, powered by chemical reactions in trioesters catalysed by enzymes, based C. de Duve, about combining their congruity. Principles is intended to assist in understanding how chemistry primary metabolic cycles functioned and, above all, researchers have to realize that the suggestions, as it could run, and can be found in modem metabolic pathways of cells. This mechanism, as pathways of archaic chemistry evolved, are a valuable contribution to the development of research on the origins of life on Earth.